Health & Fit Ultrasound exams associated with autism in study, others say no

20:26  12 february  2018
20:26  12 february  2018 Source:   cnn.com

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The number and duration of ultrasound exams is not associated with a future diagnosis of autism in children but deep ultrasound wave penetration is, study says .

The greatest link is among kids with certain genetic variations associated with autism ; 7 percent of the And the second question is why are kids with autism so different from each other ? This study looked at only one of them -- ultrasound . As a mother of two, Webb said given what she knows now

  Ultrasound exams associated with autism in study, others say no © Shutterstock The number and duration of ultrasound exams is not associated with a future diagnosis of autism in children but deep ultrasound wave penetration is, study says.

Ultrasound exams during pregnancy are common.And researchers have now looked at whether a diagnosis of autism spectrum disorder is more likely among children exposed to this technology in the womb. 

There is no association between the number or duration of prenatal ultrasounds and a later diagnosis of autism in the child, according to a new study published Monday in JAMA Pediatrics.

However, the researchers did find a statistical association between deep ultrasound wave penetration during the first and second trimesters and autism.

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I’ve seen reports about first trimester ultrasound exams being associated with autism . You may be referring to the news headlines that followed a recent study about ultrasound and autism symptoms. In other words, it didn’t find that ultrasound caused autism .

2012 Aug;31(8):1261-9. Ultrasound and autism : association , link, or coincidence? Dr. Roy Benaroch, MD ,Many other Radiologists and scientists said that Vanity ultrasounds to take A later study in Lancet found similar effect on fetal growth in women receiving repeated ultrasound exams

"Depth of penetration has to do with the distance between the ultrasound transducer (probe) on the skin and the point at what you're looking at on the ultrasound," said Dr. Jodi Abbott, a co-author of the new study and a physician with Boston Medical Center.

The depth -- as indicated on the image and as read by the authors for the study -- is the farthest down the ultrasound beam reaches, explained Dr. Jacques S. Abramowicz, who is chair of the safety committee of the World Federation of Ultrasound in Medicine and Biology. "It has nothing to do with where the fetus and his/her parts are. The depth could indicate 20 cm and the fetus be at 12 cm," he said. Abramowicz did not participate in the new research.

Absorption of the wave traveling through tissue increases with frequency, so the higher the frequency, the shallower the ultrasound penetrates, according to the Journal of Ultrasound in Medicine. Ultrasound technology gives the technician some leeway in adjusting the frequency to get a better image of the fetus.

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For those of you who’d like even more detail, an excellent review of these and many other studies about ultrasounds and autism is here (unfortunately the full article is behind a paywall.)

The greatest link is among kids with certain genetic variations associated with autism ; 7 percent of the And a second question is, why are kids with autism so different from each other ? This study looked at only one of them – ultrasound . As a mother of two, Webb said given what she knows now

Depth of penetration "varies based on the size of the woman and the amount of tissue that she has on her belly between the transducer and the fetus," said Abbott. This is not something a woman can control, she said.

Dr. N. Paul Rosman, first author of the study and a pediatric neurologist at Boston Medical Center, emphasized that an association does not prove cause and effect. The study results, then, do not mean that ultrasounds cause autism.

"We think this study was done well but there are deficiencies, and that's why we call for additional studies," said Rosman. Other researchers say that the methodology of the study was not rigorous enough to draw firm conclusions.

Comparison groups

Autism spectrum disorders are a group of developmental disabilities characterized by challenges with social skills, speech and nonverbal communication. About 30% of people with autism have a defined genetic abnormality, said Rosman, while another 20% of cases are due to recognizable diseases such as a mother who gets rubella while pregnant. No specific cause has been determined for the remaining 50% of cases, he said.

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The greatest link was found among children with certain genetic variations associated with autism . “If we can figure out this information in any other way, I would go with that,” she said . They will also study if it is possible that ultrasound exposure actually contributes to autism incidence – though

The greatest link was found among children with certain genetic variations associated with autism . “If we can figure out this information in any other way, I would go with that,” she said . They will also study if it is possible that ultrasound exposure actually contributes to autism incidence – though

Over the past few decades, the prevalence of autism has steadily increased. The disorder affects one in every 68 people, according to the US Centers for Disease Control and Prevention. During the same few decades, expectant mothers have undergone an increasing number of ultrasound exams. Some past research has suggested but not proven that autism may be associated with frequent prenatal ultrasound exams.

To investigate, Boston Medical Center researchers looked at the medical records of 420 children; 107 of these children had been diagnosed with autism.

The researchers examined the sonograms of each child with autism and compared these images to those of two typically-developing children and those of one child with a developmental delay.

A higher frequency of prenatal ultrasounds was not seen in the autism group.

The children with autism received, on average, about 5.9 scans, estimated the researcher. Typically developing children averaged 6.3 scans while children in the developmental delay group averaged 6.1.

The autism group also had not been exposed to longer ultrasound sessions. Compared with the typically developing group, children with autism experienced a shorter duration of ultrasound exposure during the first trimester (290.4 seconds vs 406.4 seconds) and second trimester (1,687.6 seconds vs 2,011.0 seconds), the researchers found.

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Fetal ultrasound , which uses sound waves to gain a view inside the womb, can determine the date of conception, identify multiple fetuses and detect various abnormalities, among other valuable medical information. In a press release issued this month in response to the Autism Research study

association between prenatal ultrasound exposure and autism , but there are very little data on human fetal exposure Autism is associated with some perinatal and obstetric conditions. Many studies have presented evidence for and against association of autism with viral infection after birth.

"Despite the increased number of ultrasounds over the years, the concerning findings in the past have not been borne out in the study," said Abbott.

Yet, one important difference between groups of children was seen: The autism group averaged greater depth of penetration than typically developing children during the first trimester (12.5 cm vs 11.6 cm) and second trimester (12.9 cm vs 12.5 cm). These differences are statistically significant, noted the study authors.

Similarly, depth of penetration in the first trimester for the autism group was also greater than the developmental delay group (12.5 cm vs 11.6 cm).

Rosman suggested readers "look at the study critically." He and his colleagues did not examine multiple factors that might affect a child in the womb, including whether a woman became ill or smoked during her pregnancy.

It is necessary, he said, to do more research to verify the new findings, said Rosman. If future research supports these results, he has a theory why ultrasounds and autism may be linked: It has to do with fetal brain development.

"The cells that give rise to the mature brain originate deep within the brain and migrate outward to form the mature cerebral cortex," he said. "They do this in a very orderly fashion -- one generation of cells following another."

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The greatest link is among kids with certain genetic variations associated with autism ; 7 percent of the And the second question is why are kids with autism so different from each other ? This study looked at only one of them — ultrasound . As a mother of two, Webb said given what she knows now

In this autism - ultrasound study , the authors do not report associations of their endpoints with second- or third-trimester ultrasounds . The other significant result is for clinician-reported repetitive behaviors, with higher scores in association with ultrasound .

If the ultrasound waves penetrate deeply, they may disturb the deep-lying cells within the brain and "potentially interfere with their migration outward to form a normal cerebral cortex," said Rosman.

Persuasive theories aside, other scientists say pregnant women should not fear a medically-necessary ultrasound exam.

Differences 'not significant'

Dr. Marvin Ziskin, a professor of Radiology and Medical Physics at Temple University's School of Medicine, said, "Unfortunately, the authors do not appear to know what is meant by the ultrasound penetration depth. It does not relate to the amount of ultrasound entering the body."

Ziskin was not involved in the study.

"The factors that determine the amount of ultrasound entering the body, and what would affect the fetus, are the mechanical index, the thermal index, and ultrasound power and intensity, for which no significant differences were found," said Ziskin. "The amount of ultrasound imparted into pregnant patients has no association with autism spectrum disorder."

Abramowicz, who is also a professor and director of Ultrasound Services in the Department of Obstetrics and Gynecology at the University of Chicago, also said the study methodology is "completely flawed."

"As the ultrasound penetrates the tissues it actually loses energy," he said. "The difference between the groups of children is minimal in terms of the depth. And clinically not significant."

The research team also examined the scans retrospectively and were not present when they were taken and this is another study flaw, Abramowicz said. They could not know, he said, how long an ultrasound exam lasted based on the timestamps on the first and last sonograms of a session. There could have been half an hour of scanning before the technician took the first image and another half hour of scanning after the last, he explained.

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The greatest link is among kids with certain genetic variations associated with autism ; 7 percent of This study looked at only one of them— ultrasound . As a mother of two, Webb said given what she (HealthDay)—Children with autism learn new words the same way as other children do, but it takes

The greatest link is among kids with certain genetic variations associated with autism ; 7 percent of the And the second question is why are kids with autism so different from each other ? This study looked at only one of them -- ultrasound . As a mother of two, Webb said given what she knows now

Asked if individual technicians control depth of penetration, Abramowicz said the newest machines, when in obstetric mode, simply cannot penetrate deeper than what is safe for a fetus.

Finally, the authors claim that ultrasound technology is "minimally-regulated," a claim to which others also take exception.

"It is extremely regulated," said Abramowicz, "particularly in the United States, with the Food and Drug Administration looking very closely at the machines."

What is true is that ultrasound usage is less regulated, he said. Still, any patient whose ultrasound exam is done by a qualified medical technician is safe.

However, the American Pregnancy Association notes that commercial keepsake ultrasound services, which offer families a sneak preview of their growing baby, have opened across the nation. An expectant mother should never undergo an ultrasound in a shopping mall or other commercial space to obtain a "keepsake" sonogram.

"Absolutely not!" said Abramowicz.

Thomas Frazier, chief science officer of Autism Speaks, said the new study doesn't provide "enough evidence to make a recommendation for or against ultrasound."

Uninvolved with the research, Frazier added that even if depth of ultrasound somehow increased the risk of autism, it would likely be "a small increase in risk and autism would not be due specifically to ultrasound in most cases."

"Please don't cause any undo fear in the minds of pregnant women. They have enough to worry about," Ziskin said. If anything, the study "should give expectant mothers confidence that ultrasound will not cause autism spectrum disorder or delayed development," he said.

Getting kids to a good weight by 13 may help avoid diabetes .
<p>There may be a critical window for overweight kids to get to a healthy level, a large study of Danish men found.</p>Diabetes can develop when the body can't properly use insulin to turn food into energy. Being overweight at any age raises the chances of the most common form, Type 2. But it's not known whether or how much that risk is reduced if people lose weight, and when.

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