Health & Fit Glucosamine supplements don’t help knee or hip arthritis pain

03:05  11 august  2017
03:05  11 august  2017 Source:   Reuters

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public found that at both three-month and 24-month follow-up points, the supplement had no effect on either hip or knee pain from arthritis . Five of the six studies investigated knee osteoarthritis, and one looked at hip osteoarthritis. Overall, the effects of glucosamine and the placebo on pain and

Unlike several arthritis supplements that you may have heard of―like Supple for example―Instaflex has a clinical study showing that it might help some people. Most glucosamine sulfate research finds that it seems to help the most with knee arthritis pain .

(Reuters Health) - Oral glucosamine, a natural supplement often marketed for joint pain, has no more effect than a dummy pill, according to a new review of available research.

The analysis of randomized controlled trials from which data have been made public found that at both three-month and 24-month follow-up points, the supplement had no effect on either hip or knee pain from arthritis.

Even analyses of the results for sub-groups of study participants, such as overweight people or those with high inflammation, found no benefit with the supplements.

“Most recent guidelines conclude there is an overall lack of efficacy of glucosamine, however, we knew that osteoarthritis could affect subgroups differently,” said senior study author Sita Bierma-Zeinstra of Erasmus University Medical Center in Rotterdam, the Netherlands.

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In this Article. What Are Glucosamine and Chondroitin? Which Brand of Arthritis Supplement Should I Use? Gout: Risk Factors and Triggers. Knee and Hip Exercises for Osteoarthritis. further reading. How it helps arthritis , migraines, and dental pain . Coping With Pain ?

Sept 16, 2010 -- The popular supplements glucosamine and chondroitin don ' t do much to relieve the pain associated with hip or knee osteoarthritis (OA), according to a new analysis of 10 studies. This is not the first time that research has cast doubt on the effectiveness of these two supplements .

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The most recent report from the U.S. National Center for Health Statistics found that Americans spent nearly $13 billion in 2012 on natural product supplements, and glucosamine was one of the most popular.

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For advice on arthritis joint pain -- and supplements that can help -- WebMD turned to Sharon Plank, MD, an integrative The issue was further explored in a 2010 compilation of 10 studies, comparing glucosamine , chondroitin, or both on joint pain and X-ray findings in people with knee or hip pain .

knee or thigh; this is called referred pain . • Nutritional Supplements Glucosamine and chondroitin sulfate are nutritional supplements derived from cartilage. Research shows massage can help ease arthritis pain , improve joint function and ease stress and anxiety.

The Osteoarthritis Research Society International and the U.S. National Institute for Health and Care Excellence recently issued guidance about the lack of evidence for glucosamine as a cure for joint pain.

“Before we threw the baby out with the bathwater, however, it was important to know whether different subgroups could have some effect,” Bierma-Zeinstra told Reuters Health by email.

The researchers analyzed data from randomized, controlled trials conducted between 1994 and 2014. Of the 21 studies they found on the subject, only six shared data through the OA Trial Bank, an international collection of data from trials conducted worldwide. None of the trials included in the analysis was funded by industry, the authors note.

Five of the trials, which altogether included more than 1,600 patients, compared glucosamine with a placebo. Five of the six studies investigated knee osteoarthritis, and one looked at hip osteoarthritis.

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Glucosamine and chondroitin have been popular supplements for arthritis for years. But clinical trials in humans haven' t shown that they're any better than sugar pills at reducing pain . If you're among the estimated 27 million Americans who suffer from osteoarthritis of the knee or hip , then perhaps you've

Studies Spotlight Diet, Supplements for Knee Pain . Want More News? Sign Up for MedicineNet Newsletters! As osteoarthritis gets worse, this joint space gets narrower. Glucosamine and Arthritis : No Hip Help .

Overall, the effects of glucosamine and the placebo on pain and physical functioning didn’t differ, either in the short-term or one or two years later. The supplement was also no better than placebo among subgroups based on pain severity, severity of osteoarthritis, age, body mass index, gender or signs of inflammation.

“Of course, the most striking thing in this study is that when a commercial party funded the source, data sharing became difficult,” Bierma-Zeinstra said. “Open access to data from clinical studies, although propagated by many research organizations worldwide, is still far from common practice.”

In addition, the researchers found that data for a study published in 2006 was no longer available. Although data from older studies may disappear, that doesn’t often happen with recent ones, she added.

The research team plans to update subgroup data in the OA Trial Bank every five years. They’ll continue to contact clinical trial researchers to encourage them to contribute data to the project.

Future studies should look more closely at knee versus hip osteoarthritis and specific supplement types such as glucosamine sulfate versus glucosamine hydrochloride, the Bierma-Zeinstra’s team writes in the Annals of the Rheumatic Diseases.

“Consumers should be cautious about spending money on unproven treatments,” said Dr. C. Kent Kwoh, director of the University of Arizona Arthritis Center in Tucson.

For instance, side effects of glucosamine include heartburn, drowsiness, headaches, allergic reactions, weight gain, diarrhea and abdominal pain, said Kwoh, who wasn’t involved in the study.

“Most consumers believe that, as a ‘natural product,’ glucosamine is safe, but there are potential side effects,” he told Reuters Health by email. “There is very little evidence that oral glucosamine is beneficial for pain.”

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